Conference Talk

Abstract

Addiction triggers neuroplastic changes in the brain, reflected aberrant neural activity and connectivity. Measuring alterations in resting neural activity provides mechanistic insights to understand addiction, as well as therapeutic targets for brain stimulation based treatments. Resting-state fMRI (rs-MRI) has been extensively employed for resting neural activity measurements comparing health control and addiction subjects; yet the available results are inconsistent due to the limited sample size and heterogeneous laboratory settings. Here we performed meta-analyses with ES-SDM method, in order to identify reliable alterations of resting neural activity in addiction population. Regional homogeneity (ReHo), the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) were included for analyses based on 30 identified studies using voxel-wise whole-brain two-sample tests. The results revealed significantly increased ReHo and ALFF in the left supplementary motor area and bilateral medial cingulate, decreased ReHo and ALFF in right middle superior frontal gyrus. We also identified increased ReHo in the left precentral gyrus, left postcentral gyrus, right inferior temporal gyrus, and left middle temporal gyrus; decreased ReHo in the bilateral anterior cingulate (ACC), medial orbitofrontal cortex (OFC), bilateral ventromedial prefrontal cortex, and right dorsal prefrontal cortex. Increased ALFF/fALFF was found in the right putamen, right insula, bilateral thalamus; decreased ALFF/fALFF in left middle occipital gyrus. In conclusion, aberrant resting neural activity (e.g. Increased resting activity in a reward system and decreased resting activity in impulsivity) could serve as prognostic biomarker and functional targets for noninvasive brain stimulation treatments.

Hui Zheng

Phd Student

My research interests include neuron modulation and reinforcement learning in addiction disorder.